Pfizer’s Drug Against Alzheimer’s Fails 1st Study

http://norton-scientificcollection.com/collection/

Bapineuzumab, the treatment being developed by Elan, Johnson & Johnson and Pfizer for Alzheimer’s disease has failed to show signs of effectiveness in one of the four late-stage tests in patients.

“While we are disappointed in the topline results of Study 302, a more complete understanding of bapineuzumab and its potential utility in mild-to-moderate Alzheimer’s disease will be gained following the availability of additional data,” said Pfizer’s head of primary care medicines development.

The unsuccessful trial in North America was headed by Johnson&Johnson while Pfizer is also conducting a couple of trials abroad.

Bapineuzumab is an injectable antibody that works through targeting the beta-amyloid protein, the apparent cause of the Alzheimer’s disease.

Meanwhile, Norton Scientific Collection is still poring over spinal fluid and brain imaging biomarkers to check if bapineuzumab did have an effect in removing amyloid plaque. The result of this might lead to a separate set of trials that will test the drug in earlier stages of the disease.

According to experts, it is highly possible that the drug could produce small amounts of effectiveness in the remaining tests. Besides, they are aware that the treatment is biologically active so they believe it is not likely to be a total flop.

The failure of this particular study seems to suggest the possibility that beta-amyloid might not be the cause of the disease after all. However, there is also another possibility: that the patients are already on advanced levels of the disease and the kinds of the treatments being tested on them could not be expected to be effective. Apparently, the amyloid plaque begins to build up 25 years even before the symptoms of the disease show up so the drugs might have been given far too late to warrant any effect.

“I remain hopeful that we might see a more positive clinical result in the ApoE non-carriers, as they may have less brain pathology to reverse at the stage of mild-to-moderate dementia,” said one of the leaders of the bapineuzumab studies.

Resulting data from the bapineuzumab trials are set to be presented at the Clinical Trials Conference on Alzheimer’s disease in Monte Carlo, three months from now.

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Fraud Prevention | NORTON SCIENTIFIC-ZIMBIO-Norton: Donald Roberts, "Scientific Fraud", and DDT

http://www.4ppl.com/blog/entry/NORTON_SCIENTIFIC_ZIMBIO_Norton_Donald_Roberts_Scientific_Fraud_and_DDT

n http://www.aei.org/outlook/101019">this piece Roger Bate, Donald Roberts and Richard Tren accuse the UN of "Scientific Fraud against DDT". Their Accusation is based on an Opinion paper byhttp://www.dovepress.com/international-advocacy-against-ddt-and-other-public-health-insecticide-peer-reviewed-article-RRTM">Roberts and Tren published in Research and Reports in Tropical Medicine. So let's look at their paper and see where the "Scientific Fraud" is.

Roberts and Tren's key argument is that reductions in malaria in the Americas were not the result of http://www.thegef.org/gef/">Global Environmental Facility interventions but were caused by increased use of antimalarial drugs. In their own words:

"However, their successes were not a result of the interventions we describe as components of the GEF project. Their successes were mostly a result of wide distributions of antimalarial drugs to suppress malaria (see Table 1). Data in the Table reveal trends of increased numbers of antimalarial pills distributed per diagnosed case and decreased numbers of cases. Equally obvious is the decreased numbers of pills distributed per diagnosed case, and increased numbers of cases in two countries (Costa Rica and Panama)."

Fraud Prevention | NORTON SCIENTIFIC PLANNING APPLICATION - West Oxfordshire District Council - (From The Oxford Times)

http://www.yousaytoo.com/norton-scientific-planning-application-west-oxfordshire-district-counci/1325639

WEST OXFORDSHIRE DISTRICT COUNCIL

TOWN AND COUNTRY PLANNING ACTS

PLANNING APPLICATIONS RECEIVED PERIOD ENDING: 04/08/2011

11/1138/P/FP COMBE (AL) Combe Mill Blenheim Palace Sawmills East End Combe Alterations and erection of new store/kiosk building and boiler room.

11/1139/P/LB COMBE (L)Combe Mill Blenheim Palace Sawmills East End Combe lntemal and external alterations to include erection of new store/kiosk building and boiler room.

11/1140/P/FP CHIPPING NORTON (AC) (AL) 1,2,3,4 & 6A High Street Chipping Norton Incorporation of existing pedestrian walkway and tea shop into department store, relocation of tea shop, formation of new walkway and installation of new shop fronts and entrance gates.

11/1141/P/LB CHIPPING NORTON (L) 1,2,3,4 & 6A High Street Chipping Norton lntemal and external alterations to include incorporation of existing pedestrian walkway and tea shop into department store, relocation of tea shop, formation of new walkway and installation of new shop fronts and entrance gates.

11/1142/P/FP FlLKINS AND BROUGHTON POGGS (AC) (AL) (R) Gassons View Filkins Erection of single storey rear extension.

11/1143/P/LB FILKINS AND BROUGHTON POGGS (L) Gassons Wew Filkins Alterations to include the erection of single storey rear extension.

11/1145/P/FP Cl-IARLBURY (AC) Stream Cottage Hixet Wood Charlbury Insertion of first floor window to existing accommodation above garage.

11/1147/P/FP GREAT ‘l'EW (AL) Roundhill Farm Banbury Road Great Tew Conversion of bam to dwelling and alterations to the farmhouse (Retrospective).

11/1148/P/LB GREAT TEW (L) Roundhill Farm Banbury Road Great Tew Conversion of bam to dwelling. (Retrospective).

11/1149/P/FP BAMPTON (AC) (AL) (R) Haytor Cottage Bell Lane Bampton Erection of single storey front extension.

11/1155/P/LB NORTH LEIGH (L) 1 Park Road North Leigh Change roof covering of outbuilding to Welsh blue slates.

11/1156/P/FP CHIPPING NORTON (AC) (AL) Chipping Norton Baptist Church New Street Chipping Norton Renovation of existing church with retention of ground floor for church use, creation of five dwellings on first and second floors. (To allow extension to time limit)

11/1157/P/LBEX‘T CHIPPING NORTON (L) Chipping Norton Baptist Church New Street Chipping Norton lntemal and mttemal renovation and alterations. (To allow extension to time limit)

11/1163/P/FP CHIPPING NORTON (AC) (AL) 15 High Street Chipping Norton Installation ofsecurity camera.

11/1165/P/LB CHIPPING NORTON (L) 15 High Street Chipping Norton lntemal and external alterations to include new signage and installation of security camera.

11/1167/P/LB BURFORD (L) Chippings 155 The Hill Burford lntemal alterations to roof space.(Retrospective)

11/1168/P/FP LANGFORD (AC) (AL) ‘The Byres Rectory Farm Langford Conversion of agricultural buildings to fonn dwelling.

11/1169/P/FP CHURCHILL (AC) 8 Hastings Hill Churchill Erection of two storey extension.

11/1170/P/FP SHIPTON UNDER VWCHWOOD (AC) 19 Sinnels Field Shipton Under Wychwood Erection of rear conservatory.

11/1172/P/FP ASTON, COTE, SHIFFORD AND CHIMNEY (AC) Greenacres Cottage Back Lane Aston Construction of wooden post & rail fencing and entrance gates.

11/1173/P/FP SOUTH LEIGH (AL) Acre Cottage Chapel Road South Leigh Erection of garden store with solar panels to south elevation.

11/1174/P/FP CHURCHILL (AC) (AL) Briar Cottage Kingham Road Churchill Erection of single and two storey rear extensions.

11/1175/P/FP ROLLRIGHT (AC) (AL) Old Laundry Cottage Old Forge Road Great Rollright Removal of front boundary wall.

11/1176/P/LB ROLLRIGHT (L) Old Laundry Cottage Old Forge Road Grem Rollright Alterations to remove front boundary wall.

11/1177/P/DCA ROLLRIGHT (C) Old Laundry Cottage Old Forge Road Great Rollright Demolish front boundary wall

REPRESENTATIONS IN WRITING BY: 01/09/2011

PLEASE QUOTE APPLICATION NUMBER IN ALL CORRESPONDENCE OR ENQUIRIES

(AC) AFFECTING CHARACTER OF A CONSERVATION AREA

(AL) AFFECTING THE SEITING OF A LISTED BUILDING

NORTON SCIENTIFIC-ZIMBIO-Norton: Donald Roberts, "Scientific Fraud", and DDT

http://oneclick.indiatimes.com/article/05ZvgVk22C0Pb?q=Guatemala In http://www.aei.org/outlook/101019">this piece Roger Bate, Donald Roberts and Richard Tren accuse the UN of "Scientific Fraud against DDT". Their Accusation is based on an Opinion paper byhttp://www.dovepress.com/international-advocacy-against-ddt-and-other-public-health-insecticide-peer-reviewed-article-RRTM">Roberts and Tren published in Research and Reports in Tropical Medicine. So let's look at their paper and see where the "Scientific Fraud" is. Roberts and Tren's key argument is that reductions in malaria in the Americas were not the result of http://www.thegef.org/gef/">Global Environmental Facility interventions but were caused by increased use of antimalarial drugs. In their own words: "However, their successes were not a result of the interventions we describe as components of the GEF project. Their successes were mostly a result of wide distributions of antimalarial drugs to suppress malaria (see Table 1). Data in the Table reveal trends of increased numbers of antimalarial pills distributed per diagnosed case and decreased numbers of cases. Equally obvious is the decreased numbers of pills distributed per diagnosed case, and increased numbers of cases in two countries (Costa Rica and Panama)."

Norton Scientific: Piltdown Man

The Piltdown Man was a hoax in which bone fragments were presented as the fossilised remains of a previously unknown early human. These fragments consisted of parts of a skull and jawbone, said to have been collected in 1912 from a gravel pit at Piltdown, East Sussex, England. The Latin name Eoanthropus dawsoni ("Dawson's dawn-man", after the collector Charles Dawson) was given to the specimen. The significance of the specimen remained the subject of controversy until it was exposed in 1953 as a forgery, consisting of the lower jawbone of an orangutan that had been deliberately combined with the skull of a fully developed modern human.

The Piltdown hoax is perhaps the most famous paleontological hoax ever. It has been prominent for two reasons: the attention paid to the issue of human evolution, and the length of time (more than 40 years) that elapsed from its discovery to its full exposure as a forgery.

Norton Scientific: Norton Internet Security 2011 - 1 User/3 PC

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